QUANTIFICATION OF PROPAFENONE HYDROCHLORIDE BY HPTLC METHOD IN ITS PHARMACEUTICAL DOSAGE FORM
DOI:
https://doi.org/10.5281/Abstract
Background: Propafenone hydrochloride is an anti-arrhythmia drug which is available in tablet formulation. The aim of the present work is to develop and validate the HPTLC method for the estimation of propafenone hydrochloride in the tablet.
Materials and Methods: The optimized chromatographic condition with a mobile phase of chloroform: methanol: acetic acid (8:1.5:0.5 v/v/v), silica gel G60 F254 is used as the stationary phase.The UV detection of the spot was performed at 251 nm. Propafenone hydrochloride has an Rf value of 0.72.
Results: Propafenone hydrochloride calibration curve was found to be linear between 200 and 1000 ng/spot.The % recovery study was found to be 99.83%.
Conclusion: The suggested approach can be used to determine the amount of propafenone hydrochloride in a commercial formulation.
