THE ROLE OF HERBAL COSMETICS FOR THE MITIGATION OF THE PSORIASIS

Abstract

Psoriasis is a chronic inflammatory skin disease with a strong genetic predisposition and autoimmune pathogenicity. The potential molecular targets for psoriasis are JAK, STAT3, Interleukin 8. By inhibiting theses targets it marks in alteration in immune response and suppresses the abnormal activation of inflammatory cascade like psoriasis. The lack of possible cure and certain adverse reactions to several synthetic treatments has led to
extensive research for anti-psoriatic activity in herbal based formulation. The recent synthetic treatments available for treating psoriasis include phototherapy, oral medications like methotrexate, cyclosporine, and azathioprine but due to severe side effects of phototherapy which include pain, uneven pigmentation and scarring and certain side effects of oral medications like methotrexate increased the risk of liver fibrosis, cyclosporine can lead to hypertriglyceridemia. Due to these severe side effects which can lead to discomfort in the body. Therefore, the herbal preparations which are naturally available can avoid this problem and can be used to treat psoriasis. This review aimed for the exploration of the herbal cream formulation containing pure herbs, viz. oil extracts and methanolic extracts, extract of leaves of basil, thyme tulsi, turmeric, neem, beeswax, olive oil, rose oil assessed the antipsoriatic activity of various cream formulation.