A one-dimensional finite element model to study the effect of advection on calcium dynamic in Cardiac Myocyte Cell

Abstract

Cardiac myocytes cells which are present in the heart are responsible for the expansion and contraction of the heart. Specific calcium dynamics lead to the smooth functioning of the heart, which is still not understood clearly. Hence, a one-dimensional finite element model is proposed in this paper to study the effect of advection on calcium dynamics. In this model, different processes such as buffering, the reaction of calcium with buffers, diffusion of calcium ions, advection and source influx are considered to study individual and coordinated effects of advection on calcium dynamics. Significant boundary conditions and initial conditions based on the biophysical properties of the region have been proposed. A program has been developed in MATLAB for the entire problem and simulated to compute the numerical results. The individual and coordinated effects of advection, buffering, diffusion on calcium and source influx on calcium dynamics in cardiac myocytes cells are studied.